Views: 0 Author: Site Editor Publish Time: 2023-03-01 Origin: Site
The clinical trial results of MYMD-1, a drug known as the "strongest anti-aging drug", have been released, and this substance extracted from tobacco is expected to become the first officially approved anti-aging drug on the market. Once the news came out, it took away a lot of attention from the anti-aging class, but also because of its extraction from tobacco and controversial.
The "origin" of CBD is only worse than MYMD-1, which comes from another more addictive and harmful plant: cannabis.
Despite the notorious reputation of being an addictive plant, CBD has always held its own, trying to make a name for itself in a number of areas, including life extension.
Although cannabis is recognized as a "scourge", it has also been historically important as an agricultural crop, religious use and painkiller, and pharmacological research on it has never stopped.
Research has revealed that the main reason for the addictive and harmful properties of this plant is the cannabinoid component. The main components of the cannabinoids are a pair of "black and white twins" - THC (tetrahydrocannabinol) and CBD (cannabidiol).
As can be seen from their molecular formulae, the molecular composition of CBD and THC are identical, differing in structure only in a small detail. But it is this small structural difference that sets them on very different paths.
THC is psychoactive, producing strong addiction, hallucinations and hyperactivity at very low concentrations.
CBD is not psychoactive, not addictive, but also has multiple effects, and its effects can be shown according to its receptors, acting on different receptors in the body, will produce different effects, in these receptors, the most important than CB1 and CB2.
CB1 is the primary receptor for THC, which can function by activating CB1, and CBD works by competitively binding to this receptor with THC, thereby blocking the learning, memory and mental confusion caused by the binding of THC to CB1.
In contrast, the CB2 receptor aspect is shown to have an anti-inflammatory effect, and studies have shown that the binding of CBD and CB2 receptors can block immune cell migration and reduce the inflammatory response.
In addition to CB1 and CB2, CBD also binds to receptors such as GPR55, 5HT1-alpha, TRVR-1 and adenosine A2A, exerting anti-inflammatory, analgesic and antianxiety effects.
As the "twin" of THC, CBD has to work diligently to provide therapeutic value to help THC "redeem" itself.
With the development of science, more and more research on CBD has been done, and CBD has been found to be "great" and "excellent" in the field of anti-aging.
In 2020, the University of Mississippi team applied CBD for the first time to anti-aging in zebrafish. The study in zebrafish found that CBD intervention significantly increased female survival in old age (by approximately 20%) and increased female egg production, while decreasing the expression of senescence-associated inflammatory phenotypes (SASP).
Immediately after 2021, CGC Canada applied nematodes to carry out experiments on the resistance to decay of CBD. The results showed that 40 μM of CBD intervention significantly increased nematode resistance to high temperature by 141% and maximum life span by 18%, while late life activity increased by 206%.
Also, although the effect of CBD intervention can vary at different doses, it was not toxic to nematodes even at up to 4000 μM.
Although the life extension effect has only been produced on two lower model organisms so far, the life extension effect and safety of CBD is also evident, laying the foundation for other animal experiments and clinical trials in the future.
Putting aside the "life extension" angle, CBD can play a role in various age-related diseases/symptoms, and in recent years, these anti-aging effects have been slowly identified and confirmed by researchers in varying degrees.
One of the more established points in this is the neuroprotective effect. As early as 2010, CBD intervention studies on neurodegeneration associated with aging began. CBD is also recognized as a major player in neuroprotective in the elderly and animals.
Earlier we learned that CBD can alleviate the learning, memory and psychotic effects of THC, so here we are going to introduce that CBD can also play an active role in neuronal pathologies mainly through anti-inflammatory antioxidant, reversing protein misfolding and promoting autophagy to fight aging-related neurodegenerative pathologies, for example.
The neuroinflammation phenomenon is a complex response to neuroglial activation associated with inflammatory mediators such as SASP. And CBD is able to reduce the secretion of inflammatory cytokines and inhibit microglia activation by activating PPAR-γ (peroxisome activated receptor γ), greatly reducing the effects of inflammatory aging on the brain.
Decreased autophagy activity of neuronal neurons in the neural ring is also an important cause of neuropathy. And CBD can induce neuronal autophagy, increase autophagy activity during aging, rescue the decrease of autophagy activity, and regulate autophagy and neuronal aging by sir-2.1.
In addition to fighting neurodegeneration, among other things, CBD can significantly improve age-related skin health problems, mobility problems, inflammatory disease problems and digestive problems.
Although CBD has been shown to have broad medicinal value as well as safety, it has had an extremely difficult road to translation.
There is only one pure CBD drug currently approved for marketing by the FDA: Epidiolex, approved in June 2018 for the treatment of 2 rare, severe, childhood-onset epileptics. However, CBD is still struggling in terms of broader applications.
And this is mainly because, CBD is strictly controlled both domestically and internationally. CBD has been regulated as a narcotic in the international convention on narcotics, the 1961 Convention. In our country, as far as the current CBD production technology is concerned, the conversion of CBD to THC is induced by carbon dioxide and water in the air, so we still maintain a firm ban on the medical use of CBD.
Although people are still cautious and skeptical about CBD due to its "origin" and being dragged down by its "dark twin", the future of CBD is still "bright" as more and more medicinal values of CBD are discovered and the purification and preservation techniques of CBD are being improved. The future of CBD is still "bright" as more and more medicinal values of CBD are explored, and the purification and preservation technology of CBD is constantly improved. Perhaps in the near future, CBD will be able to enter the clinic safely and efficiently, adding to the cause of human health.
